GayBlade is an action role-playing game designed by Ryan Best and released in 1992. It is one of the earliest examples of an LGBT-themed video game.

GayBlade is an action role-playing game in which players explore a dungeon and defeat enemies representing opponents of homosexual rights, including conservative politicians, rednecks, and televangelists. The game's final boss is Pat Buchanan, a real-world conservative politician who had been particularly outspoken against the LGBT community.

GayBlade was developed by Ryan Best and released for Mac OS in 1992, with Paul Ray handling the Windows version. Best was motivated to develop the game in response to growing homophobic commentary throughout political and religious communities, particularly in response to the AIDS epidemic in the 1980s.

Best and GayBlade were featured in the 2020 Netflix documentary 'High Score.' At the time of filming, Best believed that all of the master copies and source code for GayBlade had been lost during a move. While the series was in post-production, the producers were contacted by an LGBT museum in Berlin, Germany called Schwules Museum; the museum had a copy of the game, and shared it with the producers. The game was subsequently made available on for online emulation and download.